On your marks, get SET(D1A): the race to protect stalled replication forks
نویسندگان
چکیده
منابع مشابه
DNA Replication: Pif1 Pulls the Plug on Stalled Replication Forks
The conserved PIF helicase family appears to function in replication to ensure termination and passage through regions that slow or arrest replication fork movement. Findings in fission yeast extend evidence from budding yeast, and argue for universal mechanisms that ensure replication integrity.
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RecG and RuvAB are proposed to act at stalled DNA replication forks to facilitate replication restart. To clarify the roles of these proteins in fork regression, we used a coupled spectrophotometric ATPase assay to determine how these helicases act on two groups of model fork substrates: the first group mimics nascent stalled forks while the second mimics regressed fork structures. The results ...
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HUWE1 is a multi-faceted E3 ubiquitin ligase of the HECT family with many confirmed substrates, but mechanistic understanding of its functional roles in signaling pathways remains limited. In this issue of EMBO Reports, Choe et al demonstrate a novel function for HUWE1 in promoting DNA damage tolerance mechanisms to bypass DNA lesions during replication stress, thereby preserving genome stabili...
متن کاملMultiple pathways process stalled replication forks.
Impairment of replication fork progression is a serious threat to living organisms and a potential source of genome instability. Studies in prokaryotes have provided evidence that inactivated replication forks can restart by the reassembly of the replication machinery. Several strategies for the processing of inactivated replication forks before replisome reassembly have been described. Most of...
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The preparations for the opening of the Graduate Academy (GA) have been in full swing since February this year: The first members of staff have begun their work, concepts have been developed, rooms occupied and a website designed. Since August 1, the GA's doors have been open to everyone who is interested in what we do. As an interdisciplinary service point for young researchers, the GA is aime...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2018
ISSN: 2372-3556
DOI: 10.1080/23723556.2018.1511209